RED HOT PROPERTY by Devin O'Branagan. It will make you laugh and make you cry. It is, as the critics say, entertaining, heartbreaking, and hilarious. www.RedHotNovel.com
I just finished The Elegance of the Hedgehog by Muriel Barbery, that made me laugh and cry, it was a wonderful book, I lent it to a friend and she had the same reaction, although she said she found it a bit intellectual for her taste, lots of discussion of language, philosphy and art.
For me, Anne of Green Gables is the original gangsta tearjerker: so many sad, happy, beautiful moments.
The Time-Traveler's Wife by Audrey Niffenegger
We Are All Welcome Here by Elizabeth Berg--anything by Elizabeth Berg, for that matter.
In the nonfiction arena, John Adams by David McCulloch: the last few chapters.